The present study investigates the effects of gm1 on the memory impairment induced by scopolamine in rats or mice tested in passive pa and discriminative avoidance da tasks, respectively. Naringenin protects against scopolamineinduced dementia. Klinkenberg i, blokland a 2010 the validity of scopolamine as a pharmacological model for cognitive impairment. In the acute scopolamine induced memory impairment in rats as depicted in figure 3 a1, the percentage of recognition index for the positive control donepezil 1 mgkg, negative control scopolamine 1 mgkg and the os extract treated groups, were found to be unchanged, indicating that the acute scopolamine induced memory was not impaired f. Genistein ameliorates scopolamineinduced amnesia in mice. Memory impairment was induced in male wistar rats by administration of scopolamine 1 mgkg intraperitoneally. The radial arm maze and passive avoidance tests were performed to evaluate. To determine if ht1001, an extract of american ginseng, affects scopolamine induced memory and performance deficits in a spatial learning task, alters brain concentrations of aminergic neurotransmitters, and alters choline uptake in synaptosome preparations. Antiamnesic effect of aqueous extract of crataeva nurvala.
Pdf antiamnesic activity of vitex negundo in scopolamine. Posttreatment of rats with bso mitigated scopolamineinduced amnesia, by reducing latency period and increasing percentage alternation and histological changes. Effects of atropine on discrimination learning in the rat. Animal model of alzheimers disease scopolamine induced. Effect of tacrine and rivastigmine on scopolamine induced impaired consolidation of passive avoidance memory there was a significant increase p in tlt. Noteworthy, the response induced by the pretest injection of isoprenaline plus scopolamine was antagonized with atenolol. Naringenin protects against scopolamineinduced dementia in rats. In the acute scopolamineinduced memory impairment in rats as depicted in figure 3 a1, the percentage of recognition index for the positive control donepezil 1 mgkg, negative control scopolamine 1 mgkg and the os extract treated groups, were found to be unchanged, indicating that the acute scopolamineinduced memory was not impaired f 5, 38 0. Memory impairment amnesia in male albino rats induced by scopolamine hydrochloride was recorded as transfer latency time tlt in epm model. Effect of resveratrol on scopolamineinduced cognitive. International journal of pharmtech research coden usa. Scopolamine is muscarinic receptor antagonist with amnestic properties that have been used for decades in experimental rats to induce impairment in their performance of a variety of tasks requiring intact working and reference. Ht1001 demonstrates a capacity to protect against scopolamineinduced memory deficits. Evaluation of neuroprotective effect of quercetin with.
Antiamnesic activity of vitex negundo in scopolamine induced amnesia in rats. In control group no drug was given and only diet and water were provided. Aug 02, 2016 imam a, ajao ms, ajibola mi, amin a, abdulmajeed wi, lawal az, et al. The underlying mechanisms involve the regulation of the hippocampal cholinergic system and neurogenesis via activation of bdnf. Antiamnesic activity of vitex negundo in scopolamine. We evaluated the neuropharmacological effects of gongjindan gjd on the memory impairment caused by scopolamine injection.
It is believed that neurophysiological effects of sesame oil on the learning process may be due to its antioxidant effects15. Scopolamine 2 mgkg ip and propranolol 55 mgkg ip, given before a single learning trial, reduce retention of a passive avoidance response in rats. Jun 25, 2018 next, pretreatment of rats with embelin mitigated scopolamine induced neurochemical and histological changes in a manner comparable to donepezil. Thirtysix male balbc mice weighing around 2535 g were employed. Amelioration of cognitive deficit by embelin in a scopolamine. If the rat did not enter into one of the closed arms within 180 s, it was. Scopolamine markedly decreased the tlt over 2 min, elt, tstq over 90 sec and consecutively impaired learning and memory.
Study on evaluation of nootropic effect of piracetam and. The drug, called scopolamine, also known as the devils breath, is derived from a particular type of tree common in colombia called the borrachero tree. Gongjindan enhances hippocampal memory in a mouse model. Western michigan university, 2012 the objective ofthis study will be to establish, validate, and characterize a dry eye model in female rats induced by continuous systemic administration of scopolamine via alzet osmotic pumps for 28 days. The purpose of this research was to determine if msf 1. This study will use female rats as a model for dry eye and will be implanted with osmotic pumps that will continuously distribute scopolamine or saline systemically over. Each animal received session of 15 trials with inter trial duration of 15 s for 5 days. The present study was undertaken to investigate the in vivo ability of hydroethanolic crude extract of crinum macowanii to ameliorate memory impairment induced by scopolamine. For this to be done, 10 shamoperated and 30 postmenopausallike rats were randomly distributed in eight groups and treated with distilled. Pdf memory enhancing activity of momordica charantia by. Combretaceae is a traditional herbal medicine that is widely used in the treatment of diabetes, immunodeficiency diseases, and stomach ulcer in asia. To determine if ht1001, an extract of american ginseng, affects scopolamineinduced memory and performance deficits in a spatial learning task, alters brain concentrations of aminergic neurotransmitters, and alters choline uptake in synaptosome preparations.
The present study was undertaken to investigate the effect of momordica charantia on cognitive functions, total cholesterol levels and cholinesterase che activity in scopolamineinduced amnesia in rats. The results were similar to the previously reported cognitive enhancement effects of total soy isoflavones at the dose of 40 mgkg in the scopolamineinduced amnesia model. Study was undertaken to evaluate the nootropic effects of piracetam and modafinil in scopolamine induced amnesia in rats. More, modulation of working memory by mentat and donepezil using scopolamine induced amnesia in rats, american journal of pharmtech research, vol. Read effects of molsidomine on scopolamineinduced amnesia and hypermotility in the rat, european journal of pharmacology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. This study was designed to assess the role of caffeine on fertility parameters in testicular and epididymal tissues of scopolamine. For the induction of amnesia, 1 mgkg scopolamine hydrobromide was administered intraperitoneally once a day for 14 days. Exposure of timedpregnant cd rats to scopolamine hydrobromide dissolved in distilled water 0, 10, 100, 450, or 900 mgkgday by gavage on gestational days 615 produced the following results. Phosphatidylserine, 3060 mgkg ip, antagonizes the amnesic effect of scopolamine but not that of propranolol. Effect of aqueous piper betle leaf extract against scopolamine induced amnesia on albino rats article pdf available in journal of chemical and pharmaceutical sciences 101. Memory impairment induced by intracerebroventricular icv injection of scopolamine hydrochloride 10. Scopolamineinduced amnesia is a very well recognized animal model of memory dysfunction, widely used to test potential drugs of anti.
Frontiers ethanolic extract of orthosiphon stamineus. Enduring effect of scopolamine on memory impairment has been shown by seifhosseini and colleague recently 24. Wistar rats 180200 g were trained on active avoidance task. These research findings suggest that embelin is a nootropic compound, which also possesses an antiamnesic ability that is displayed against scopolamine induced memory impairment in rats. It is seen also with slow acting parenteral general anaesthetics. May 14, 2012 the drug, called scopolamine, also known as the devils breath, is derived from a particular type of tree common in colombia called the borrachero tree. Scopolamine injection significantly induced the lipid peroxidation in hippocampus p pdf available in journal of chemical and pharmaceutical sciences 101. The observed antiamnestic effect of bso makes it a promising antiamnesic agent for clinical trials in patients with cognitive impairment. The present work was undertaken to evaluate the ability of f. It has been shown that the reduction in acetylcholinesterase ache activity which reduces. Methanesulfonyl fluoride msf blocks scopolamineinduced.
At doses or 100 mgkgday scopolamine hydrobromide, a marginal nondoserelated. The animal model of scopolamine scopinduced amnesia is widely. Behavioural neurology hindawi publishing corporation. May 14, 2015 scopolamine injection significantly induced the lipid peroxidation in hippocampus p in dg, p in ca3, shown as a deep red color in the dentate gyrus dg and cornu ammonis 3 ca3. Lee js, kim hg, lee hw, han jm, lee sk, kim dw, saravanakumar a, son cg.
Gongjindan enhances hippocampal memory in a mouse model of scopolamineinduced amnesia. Enduring amnesia induced by icv scopolamine is reversed by. Scopolamineinduced amnesia can be prevented by heat shock. Molecules free fulltext cognitive facilitation and. Reversal of scopolamineinduced amnesia by phosphatidylserine. American ginseng extract reduces scopolamineinduced.
The present study examined whether amnesia induced by scopo lamine could be counteracted in mice by arecoline, a choli nergic agonist, or by other drugs. Ganglioside gm1 attenuates scopolamineinduced amnesia in. Gongjindan enhances hippocampal memory in a mouse model of. Scopolamineinduced dryeye model in female rats ryan alderson, m. Antiamnesic activity of vitex negundo in scopolamine induced.
One hundred and twenty two female spraguedawley albino rats were trained and retention tested in a ymaze brightness discrimination task. Amnesia may be therapeutic for medical treatment or for medical procedures, or it may be a sideeffect of a drug, such as alcohol, or certain medications for psychiatric disorders, such as benzodiazepines. The retention of the passive avoidance response is not affected by phosphatidylserine given alone. Sep 01, 2010 read scopolamine and diazepam induced amnesia are blocked by systemic and intraseptal administration of substance p and choline chloride, peptides on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Aug 31, 2001 read effects of molsidomine on scopolamine induced amnesia and hypermotility in the rat, european journal of pharmacology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Hence, these findings suggest that heat shock pretreatment has a protective, rather than therapeutic, effect on the scopolamineinduced amnesia. Georgievakotetarova mt, kostadinova ii 20 effect of atorvastatin and rosuvastatin on learning and memory in rats with diazepam induced amnesia. The results were similar to the previously reported cognitive enhancement effects of total soy isoflavones at the dose of 40 mgkg in the scopolamine induced amnesia model. Scopolamine, an anticholinergic drug, causes amnesia in humans and also impairs. On the other hand, the scopolamine induced amnesia cannot be reversed by posttreatment with heat shock. Short communication effect of resveratrol on scopolamineinduced cognitive impairment in mice rachna gupta1, lalit k. Neuroprotective effects of soy isoflavones on scopolamine. Aim of the study was to evaluate the antiamnesic effects of crataeva nurvala stem bark in scopolamine induced amnesia in rats.
We concluded that memory impairmentinduced by scopolamine is. Adult male rats were treated with scopolamine with or without caffeine. Deficits induced by scopolamine in 3 mouse strains as assayed in the tmaze. Amnesia induced by scopolamine has been widely used to understand the biochemical and behavioral. After injection of scopolamine, each rat was placed in the shuttle box and. Some experimental evidence suggests that the beneficial effects of monosialoganglioside gm1 on learning and memory could be related to an improving effect in central cholinergic function. Balbc mice were orally treated with gjd 100, 200, or 400 mgkg, daily or tacrine tha, 10 mgkg for 10 days, and scopolamine 2 mgkg was injected intraperitoneally.
Effect of tacrine and rivastigmine on scopolamineinduced impaired consolidation of passive avoidance memory there was. On the other hand, the scopolamineinduced amnesia cannot be reversed by posttreatment with heat shock. The standardized aqueous extract of crataeva nurvala aecn was freshly dissolved in distilled water and administered orally to rats at the dose of 500 mgkg for evaluation of its effects against scopolamine 3 y. In the present study we investigated the antiamnesic activity of vitex negundo in scopolamine induced amnesia in rats. Also, we found that in comparison to the salinetreated animals, the injection of scopolamine to rats after training, caused memory destruction. Pdf effect of aqueous piper betle leaf extract against.
Effect of seabuckthorn extract on scopolamine induced. Each column, center line in the column and the bars. Since, scopolamineinduced memory impairment is associated with brain oxidative stress and oxidative stress is one of. Effects of molsidomine on scopolamineinduced amnesia and. American ginseng extract reduces scopolamineinduced amnesia. In the present study, we investigated the effect of treadmill exercise on spatial learning ability in relation with cell proliferation in the hippocampus using the scopolamine induced amnesia mice. Evaluation of neuroprotective effect of quercetin with donepezil in scopolamineinduced amnesia in rats.
Caffeine improves sperm quality, modulates steroidogenic. The present study investigates the effects of gm1 on the memory impairment induced by scopolamine in rats or mice tested in passive pa and discriminative. Taken together, this study strongly showed that gjd exerted antiamnesic actions in a mice model of scopolamineinduced amnesia. Black seed oil ameliorated scopolamineinduced memory dysfunction and corticohippocampal neural alterations in male wistar rats. Observed maternal or developmental toxicity at 10 mgkgday. In the present study we have investigated the therapeutic efficacy of anthocyanins in an animal model of cognitive deficits, associated to alzheimers disease, induced by scopolamine. Antiamnesic and neuroprotective effects of low dose of. Oct 19, 2015 a comparative study of cucurbita maxima and bambusa arundinacea in streptozotocin and scopolamine induced amnesia in rats. Terminalia chebula extract prevents scopolamineinduced. Black seed oil ameliorated scopolamineinduced memory. Hence, these findings suggest that heat shock pretreatment has a protective, rather than therapeutic, effect on the scopolamine induced amnesia.
Abstracttwo omega3 fatty acids including docosahexaenoic acid dha and. Scopolamine induced amnesia is a very well recognized animal model of memory dysfunction, widely used to test potential drugs of antialzheimers properties 23. To investigate the potential role of ramipril and losartan in preventing scopolamineinduced memory impairment in rats. Antiamnesic effects of a hydroethanolic extract of crinum. A study on scopolamine amnesic mice bioline international. Preventive effect of nstearoylethanolamine on memory. Full text get a printable copy pdf file of the complete article 2. Read scopolamine and diazepaminduced amnesia are blocked by systemic and intraseptal administration of substance p and choline chloride, peptides on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at. The amnesia induced by scopolamine represented the main symptom of. The rats were fed with standard rat chow pellet and water ad libitum. Dementia was induced at the end of the treatment period by a single injection of scopolamine 20 mgkg. In the present study, we investigated the effect of treadmill exercise on spatial learning ability in relation with cell proliferation in the hippocampus using the scopolamineinduced amnesia mice.
Pdf in the present study we investigated the antiamnesic activity of vitex negundo in scopolamine induced amnesia in rats. Crinum macowanii has been found to contain alkaloids that have activity against acetylcholinesterase enzyme in vitro. To investigate the potential role of ramipril and losartan in preventing scopolamine induced memory impairment in rats. Kshirsagar1 1sudhakarrao naik institute of pharmacy, pusad,m. This article is from iranian journal of pharmaceutical research. Find support for a specific problem on the support section of our website. The present study was designed to determine whether t.